Mary & May Spicule Collagen PDRN Cream

One of the most clinically advanced treatment creams in the Mary & May lineup, and arguably one of the most potent at-home regenerative formulas available in Korean skincare today. The Spicule Collagen PDRN Cream brings together three high-performance ingredients in a concentrated 15g format that delivers results far exceeding what its size suggests.

The standout ingredient here is Spicule — microscopic needle-like structures derived from freshwater sponge that create temporary microchannels in the skin upon application. This process, often referred to as bio-microneedling, mimics the skin-stimulating action of professional needling treatments, triggering the skin's natural repair response while simultaneously opening pathways for active ingredients to penetrate at a depth that conventional topical application simply cannot achieve.

Those pathways then deliver Collagen and PDRN directly where they are needed most. Collagen reinforces skin structure and promotes visible firmness and plumpness, while PDRN activates cellular regeneration at a biological level, supporting healing, renewal, and long-term improvements in skin quality. The combination of all three working in concert makes this a genuinely exceptional treatment for those seeking clinic-level regeneration from a home skincare product.

Due to the nature of Spicule, a temporary warming or tingling sensation during application is normal and an indication that the formula is working as intended.

Suitable for: All skin types, particularly mature, sagging, or deeply fatigued skin. Not recommended for highly reactive or broken skin. How to use: Apply a small amount onto cleansed skin and massage in gentle circular motions until absorbed. Begin with 2 to 3 times per week to assess skin tolerance, then increase frequency as desired. Follow with a soothing moisturiser.